BINTANG GUSTAMI PUTRI BUANA BLAMBANGAN, 051411131154 (2018) PENGARUH KADAR HPMC K4M TERHADAP PELEPASAN Lactobacillus casei FNCC 0090 DARI MIKROPARTIKEL DENGAN MATRIKS KOPOLIMER ASAM METAKRILAT TIPE L (Metode Spray Drying). Skripsi thesis, Universitas Airlangga.

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Abstract

Microencapsulation is a process by which an active substance (core) surrounded by a thin layer of film which protect the core from extreme environment condition. Microencapsulation can increase stability, protect probiotic through gastrointestinal tract and release it into intestine as a target organ. Morphology of microparticle is one of the factors which can affect the release of active substance. HPMC have a high viscocity to improve morphology of microparticle which can affect the release of Lactobacillus casei FNCC 0090 from microparticle. The aim of this study is to determine the effect of HPMC K4M concentration on release of Lactobacillus casei from microparticle using copolymer methacrylic acid type L matrix. In this study, Lactobacillus casei FNCC 0090 as active susbtance was made into microparticle by spray drying method with combination of HPMC K4M 0%; 0,2%; 0,3%; 0,4% and copolymer Methacrylic acid type L 1%. The effect of HPMC K4M concentration on Lactobacillus casei FNCC 0090 release efficiency from microparticle determined by using four formulation with different concentration of HPMC K4M. The result showed that the presence of HPMC K4M increased release efficiency of Lactobacillus casei from microparticle. The Release efficiency data was analyzed using One Way ANOVA of FI and FII that contain 0% and 0,2% HPMC K4M found to be statistically different.

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