AULIA RAHMAH HANIFA, 051411133044 (2018) PENGARUH SISTEM KOMPLEKS INKLUSI β-SIKLODEKSTRIN (βCD) TERHADAP STABILITAS ASAM-P-METOKSISINAMAT (APMS) PADA BERBAGAI pH. Skripsi thesis, Universitas Airlangga.

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Abstract

p-Methoxycinnamic acid (pMCA) is an antinociceptive compound originated from Kampferia galanga L. rhizome. pMCA is aromatic compound consist of methoxy, aromatic ring and alkene as non – polar group, also carboxylic acid as polar group. As a weak acid with value of pKa 4,11 pMCA molecular and ionic form is affected by pH change. On acidic environment pMCA is more unstable and susceptible to nucleophillic acyl substitution. To enhance pMCA stability, β-cyclodextrin (βCD) as complexing agent is added. βCD establish monomolecular inclusion complex to trap pMCA on βCD cavity. The stability of pMCA compund and pMCA - βCD complex has been studied at various pH (3, 4, 5, and 6). The buffer solution of 24 ppm of pMCA in various pH were performed at 50 ± 0,5°C for 24 hours at 5 sampling point (0h, 2h, 5h, 9h and 24 h). The sample was analysed by Reverse Phase (RP) High Performance Liquid Chromatography (HPLC) on their optimum and validated condition. The result showed that pMCA compound at various buffer solution (3, 4, 5 and 6) follow first order. Rate constant of pMCA compound at pH 3 is higher than the other, and most stable at pH 6. Whereas the presence of βCD could increase pMCA stability at pH 3.

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