Purwanto, Bambang Tri (2014) Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea. World Journal of Pharmaceutical Research, 3 (3). pp. 4797-4808. ISSN 2277-7105

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Abstract

Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride to produced N’-phenyl-N-benzoylurea. The CNS depressant activity test was done for the N’phenyl-N-benzoylurea compound and compared with bromisoval as the standard reference by Barbituric Sleeping Time (BST) method. The compound N’-phenyl-N-benzoylurea bound as well as the standard reference bromisoval with the protein Pro 85, In Silico method. The compound yield was 86% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compound melting point was different from the N-phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N’phenyl-N-benzoylurea. The CNS depressant activity test from N’phenyl-N-benzoylurea had a greater activity if compare with the reference compound bromisoval.

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