Esti Hendradi and Tutiek Purwanti and Bety Nurfia Puspitarini and Bianda Ida Kurnia (2009) The Characteristics and Release of Diclofenac Sodium of Niosome System in Carbomer 940 Gel Base Preparation (Niosome System of Diclofenac Sodium-Span 60-Cholesterol with Molar Ratio 1:5 :5). In: Proceeding The International Conference on Pharmacy and Advanced Pharmaceutical Sciences. Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, pp. 121-127. ISBN 978-979-95107-7-8

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Abstract

The present study was designed to determine the characteristics and release of diclofenac sodium of noisome system in Carbomer 940 gel base preparation. The compositions of niosome was diclofenac sodium, Span 60 and cholesterol 1:5:5. Diclofenac sodium non niosome system was used as a control. The evaluation included organoleptic, pH and sodium diclofenac released test of each formula. The result of drug entrapment efficiency of this system was 73.32±0.68%. The characteristics of gel preparation showed that niosomal system increases consistency, decreases pH of diclofenac sodium gel and also showed similarity of diclofenac sodium release compared with that control. The rate (flux) of diclofenac sodium release in control formula was 71.49±3.96 µg/cm2/minute½ and formula of the niosome system was 73.06±2.01 µg/cm2/minute½. It was analysed by statistic programmed SPSS 16.0 using independent-sample T-test with degree of believed 95% (α=0.05). The result showed that there was not a significant difference between each formula.

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