Esti Hendradi and Tutiek Purwanti and Anditasari and Srimaryati (2009) The Characteristics and Release of Diclofenac Sodium of Niosome System in Carbomer 940 Gel Base Preparation (Niosome System of Diclofenac Sodium-Span 20-Cholesterol with Molar Ratio 1:5 :5). In: Proceeding The International Conference on Pharmacy and Advanced Pharmaceutical Sciences. Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, pp. 121-127. ISBN 978-602-95107-7-8

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Abstract

The present study was designed to determine characteristics and release of diclofenac sodium of niosome system in Carbomer 940 gel base preparation. The composition of niosome system is diclofenac sodium-Span 20-cholesterol with molar ratio 1:5:5. Niosome was prepared by reversed phase evaporation method. Formula I was Carbomer gel contain of niosome components that are not in niosome system. Formula II was Carbomer gel with the noisome system. The evaluation of noisome characteristics included morphologic test by light microscope and Scanning Electron Microscopy (SEM), and drug entrapment efficiency (Ep). The characteristics of the gel preparation (organoleptic and pH) were investigated and in vitro releases of diclofenac sodium through cellophane membrane into buffer phosphate saline (PBS) pH 7.40.05 at 37C were studied. Flux and pH were analyzed by statistic programmed of SPSS 16.0 using Independent-sample t test with degree of believe 95% (α = 0,05). The result showed that the average of entrapment efficiency was 50.34 % ± 2.82. The characteristics of niosome system (formula II) preparation didn’t have effect on consistency and color of diclofenac sodium gel preparation, but this system results specific odor if it was compared with that of control. The result showed that pH of formula I (control) was 6.23 ± 0.05 and formula II (niosome system) was 6.16 ± 0.11. Flux of diclofenac sodium in formula I was 55.03 ± 2.66 μg/cm²/menit1/2 and formula II was 55.07 ± 1.31 μg/cm²/menit1/2. The statistic analyze of pH and flux of diclofenac sodium showed that were not significant different between formula I and II

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