Retno Sari and Titin Suhartanti and Dwi Setyawan and Esti Hendradi and Widji Soeratri (2014) Chitosan Based Particulate Carrier of Diterpene Lacton of Sambiloto Prepared by Ionic Gelation-Spray Drying : Effect of Stirring Rate and Nozzle Diameter. In: Proceeding the 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 222-224. ISBN 978-602-72333-0-0

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Abstract

Chitosan, a catonic polysaccharide has many advantages as carrier for drug delivery system such as biocompatble, biodegradable and non toxic.Chitosan has amino group that could be crosslinked with polianion such as tripolyphosphate so that the actve ingredient will be entrapped (Agnihotri, 2004, Sinha, 2004). Diterpene lactone fracton of sambiloto (Andrographis paniculata) has antmalarial actvity but it has low solubility in water. Entrapped diterpene lactone into chitosan matrix could improve the bioavailability of the actve substance. The aim of this research is to investgate the effect of process parameter of chitosan carrier preparaton : strring rate (500 rpm and 1000 rpm) during ionic gelaton and nozzle diameter (0.5 mm and 1.0 mm) of spray dryer on physical characteristcs of diterpene lactone fracton-chitosan partcles. Evaluaton of morphology, thermal analysis and drug entrapment were conducted

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