Anisa Rizki Amalia and Riesta Primaharinastiti and Esti Hendradi (2014) Effect of Comparison Surfactant and Cosurfactant in Water/Oil Microemulsion in release of Ovalbumin (Microemulsion Water/Oil with Surfactant (Span 80-Tween 80) : Cosurfactant (Ethanol) =5:1, 6:1, and 7:1). In: The First International Conference on Pharmaceutics and Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 18-20. ISBN 978-602-72333-0-0

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Abstract

Topically administering vaccines are currently being developed because of many bacterial and viral pathogens are able to enter the body through the skin1). Topical administraton has the advantage, among others, to avoid the frst-pass effect in the liver metabolism, prevent degradaton in the gastrointestnal tract, as well as easier to use and comfortable for the patent2). Therefore we need a system that is capable of delivering the vaccine to be able to penetrate the skin. Microemulsion is a stable colloidal dispersion system is thermodynamically and consists of phases of oil, water, surfactant, and cosurfactant which forms a clear soluton with a droplet size of < 200 nm3). This system is an ideal system for use as a drug delivery has advantages because it is thermodynamically stable, ease of manufacturing process, has a low viscosity, and droplet sizes are very small so that it has a greater surface area which facilitates penetraton of the actve compound molecules into the membrane2). As a prototype vaccine protein, ovalbumin used as an actve ingredient. Therefore ovalbumin dissolved in water, it will be made the microemulsion with the type w/o (Water in oil) where ovalbumin will be in the water phase which trapped by the oil phase. With the microemulsion type w/o actve ingredient will be stable. Comparison between the surfactant and cosurfactant compositon will affect the characteristcs of the microemulsion system4). The characteristcs of this system to be a factor of the release of the actve ingredient.The aim of this study was to investgate the effects of comparison surfactant (Span 80-Tween 80): cosurfactant (ethanol) = 5:1, 6:1, and 7:1 in released of ovalbumin from microemulsion water/oil (w/o) system.

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