Destria Indah Sari and Esti Hendradi and Junaidi Khotib (2014) Effect of Menthol as Penetration Enhancer to Diclofenac Sodium Membrane-Typed Transdermal Patch Characterization. In: Proceeding the 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 43-45. ISBN 978-602-72333-0-0

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Abstract

Inflammaton is a non-specifc immune response that occurs in reacton to any type of bodily injury. The cardinal signs of inflammaton can be explained by increased blood flow, elevated cellular metabolism, vasodilataton, release of soluble mediators, extravasaton of fluids and cellular influx1. Non-Steroidal Ant-Inflammatory Drugs (NSAIDs) are drug class which commonly used to treat inflammaton. Diclofenac sodium is one of the drug class of non steroidal ant-inflammatory drugs (NSAIDs) are widely used to relieve pain and inflammaton. Absorpton of sodium diclofenac in oral delivery is very fast but only about 60% of which reaches the systemic circulaton, this is because frst-pass metabolism that occurs in the liver2. Half-life of diclofenac sodium was also very brief about 2 hours and a few other side effects such as gastrointestnal disorders (ulcers in the stomach)and the reacton idionsynchratc. One way to overcome this problem, given by way of diclofenac sodium transdermal. Diclofenac sodium is not absorbed through the skin as perfect hydrophilic can be seen from log P of sodium diclofenac of 4.42, Absorpton of sodium diclofenac into the skin can be improved by the additon of enhancers such as menthol. Adding one or more excipients could change dosage form characteristcs. This study was aimed to determine effect of menthol to patch characteristcs when it added to diclofenac sodium membrane-typed patch.

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