Esti Hendradi and Dewi Melani Hariyadi and Muhammad Faris Adrianto (2016) Microbial Assay of Cyprofloxacin in a Bone Implant Chitosan-Bovine Hydroxyapatite with Cross-Linker Glutaraldehyde towards Staphilococcus aureus ATCC25923. In: Proceeding 1st International Conference on Medicine and Health Sciences. University of Jember, Jember, pp. 100-103. ISBN 978-602-60569-3-1

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Abstract

Bone is one part of the body has an important role to support the body's physiological functions (Porter et.al., 2009). Complications of bone diseases and bone disorders caused by traumatic accidents may result in a gap (defect) on the bone. The healing process of damage or fracture is determined by the level of trauma and soft tissue damage (strobel et.al., 2011). Some cases of damage or injury to the bone can not undergo natural recovery (Porter et.al., 2009). Therefore, clinical rehabilitation to overcome the defect on the bone is expected to increase in line with population growth (Mourino et.al., 2010). Treatment rehabilitation of bone cannot be separated from the risk of infection complications. Complications of bacterial infections can be treated with antibiotics. However, in the case of a crack (defect) occurs devascularity of bone tissue so that the delivery of antibiotics to the target tissue to be blocked. This resulted in the concentration of the antibiotic to the target so low that it cannot penetrate the bacteria. The condition can lead to bacterial resistance to antibiotics (Li et al., 2010). A high dose of antibiotics in the long term experienced problems because it can cause systemic toxicity and side effects (Mourino et a1.,2010). To overcome these problems, antibiotics can be done locally using a certain drug delivery systems. The purpose of such delivery systems is to provide drug concentration in a specific location and ensure the drug release profile for a certain time period (Dubnika et.al., 2072). Drug delivery locally has several advantages, among others, (a) the systemic effects can be avoided, (b) the amount of drugs used less and secure, and (c) the efficacy and efficiency of drug delivery locally can be achieved (Harmankaya et.al., 2013). Administration of antibiotics locally also to minimize side effects and risk of toxicity compared to administration of systemic antibiotics. ln addition, antibiotics locally also allows conduction in target tissues with high concentration (Mourino et.al., 2010). The release of antibiotics on the target network is expected to last continuously for a certain time and achieve a greater concentration than the minimum inhibitory concentration {MlC). Drug delivery systems in a controlled manner (controlled release system) can help increase the bioavailability of antibiotics in target tissues. The system is designed to release the drug at the expected location at a rate appropriate for a certain time period (Mourino et a1.,2010). ln a previous study showed that a good composite is Ciprofloxacin: BHA: chitosan = 10:30:60. Cross linker with glutaraldehyde \cAl o.7% and with 10% active ingredient Ciprofloxacin can release Cyprofloxacin for 30 days (Hendradi et al, 2015). This research will be seen potency against Staphilococcus aureus ATCC25923 Ciprofloxacin for 30 days.

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