Hendradi, Esti and Purwanti, Tutiek and Listyani, Desy Dwi and Pribadi, Ika Rossalia (2009) The Influence Of Niosome System (Span 20/60-Choleaterol) on the Preparation Characteristics and the Release of Diclofenac Sodium from HPC-HEC Gel Based. In: Proceeding The Makassar International Symposium on Pharmaceutical Science (MIPS), 19 - 20 February 2009, Makassar, Indonesia.

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Abstract

The present study was designed to investigate the influence of niosome system(Span 20/60-cholesterol) on the charactenslics preparation and diclolenac sodium released from HPC-HEC (l:l) gel based. Niosome is vesicle ssstem was made from surfactant non ionic and cholesterol The compostion of niosome system of diclofenac sodium:Span 20/60:cholesterol was 1:6:6. Formulation of diclofenac sodium gel was fomrula I and II, as con- trol od HPC-HEC gel of diclofenac sodium with span 20 and 60, respectively. Than formula III and IV were HPC-HEC gel of diclofenac sodium that was prepared into niosome system with Span 20 and 60, respectively The released of diclofenac from gel formulation was done by using diffusion cell and cellophane membrane As receptor sotulion was phospate buffer saline pH 7.4 0.05 at temperature 37 0.5 C. The parameter od diclofenac sodium released study is flux. Resultby were analyzed by statistic. The result of diclofenac-Span 20/60-cholesterol showed that there was a significant difference between formula II and formula IV; formula III and formula IV. The conclusion was niosome system that was formed by Span (20/60) and cholesterol in molar ratio of sodium diclofenac , span 20, and cholesterol = l:6:6 gave influence on the preparation characteristics and increased the released of diclofenac sodium from HPC-HEC gel based. The highest released of diclofenac sodium was from niosome system consisting of sodium diclofenac,Span 60, and cholesterol with molar ratio=l:6:6

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