ANISA PUJI KUSUMANINGTYAS, 061411131165 (2018) PROTECTIVE EFFECT OF RED DRAGON FRUIT (Hylocereuspolyrhizus)PEEL EXTRACTTODUODENAL ULCERINDUCED BY ETHANOL. Skripsi thesis, Universitas Airlangga.

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Abstract

This study was aimed to investigate the protective effect of red dragon fruit (Hylocereuspolyrhizus) peel extract on histopathological changes of duodenal ulcer induced by 75% ethanol 0.5 ml/100g BW per oral. Twenty-five BALB/C male mice were randomly divided into five groups and administrated through oral gavage with different treatments for 9 days. C(-) was negative control group that received CMC Na 0.5% + aquadest, C (+) was positive control group that received CMC Na 0.5% + 75% ethanol 0.5 ml/100g BW, T(1) was treatment group that received Hylocereuspolyrhizus peel extract 250 mg/kgBW for 7 days + 75% ethanol on day 9, T(2) was treatment group that received Hylocereuspolyrhizus peel extract 500 mg/kgBW for 7 days + 75% ethanol on day 9, T(3) was treatment group that received Hylocereuspolyrhizus peel extract 1000 mg/kgBW for 7 days + 75% ethanol on day 9. The treatment was conducted for 3 days of adaptation and 9 days of total treatments. At the end of the research, all mice were sacrificed and duodenum were collected. Duodenum tissues were processed into histopathological preparation using Hematoxylin-Eosin staining. The data was analyzed by Kruskal Wallis and Mann-Whitney Test. The research showed significant different (p<0.05) among the treatment groups. The conclusion of this research is dragon fruit (Hylocereuspolyrhizus) peel extract as antioxidant could reduce duodenum damage which induced with ethanol. The optimum dose in this research was 250 mg/kgBW.

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