SAPNA KURNIA DEWI, 061511133031 (2019) PENGARUH PEMBERIAN EKSTRAK KULIT PISANG KEPOK (Musa acuminata) TERHADAP PENURUNAN KADAR MALONDIALDEHID (MDA) PARU MENCIT JANTAN (Mus musculus) YANG DIPAPAR ASAP ROKOK. Skripsi thesis, Universitas Airlangga.

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Abstract

This research aimed to determine the effect of kepok banana peel extract (Musa acuminata) that given by per oral on the decreasing of malondialdehyde (MDA) levels in lung of male mice (Muus musculus) which was exposed by cigarette smoke. The 24 experimental male mice were divided into 6 groups. The therapy was given for 14 days, all mice were sacrificed and lung MDA level were examined with thiobarbituricacid (TBA) methods. The result of the data analysis test using one-way ANOVA (Analysis of Variance). It showed that there were significant differences between the group of animals that exposed by cigarette smoke (x = 840.50+186.47nmol/g) and the group of animals that were given with extract of kepok banana peel 56 mg/kg bw (x=6471.25+69.25 nmol/g). Besides that, there was an significant difference between the groups of animals that were exposed ciggarette smoke (x=840.50+186.47 nmol/g) with the group of animals that were given with vitamin C 260 mg/kg bw (x=555.25+61.16 nmol/g). It could be concluded that extract of kepok banana peel and vitamin C could decrease MDA levels in lung of male mice which was exposed cigarette smoke. The increased therapy dose gave affect in lowering levels of malondialdehyde in lung.

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