DINDA FEBRI PERMATASARI, 061411131013 (2019) PENGARUH PEMBERIAN EKSTRAK DAUN SAMBILOTO (Andrographis paniculata Ness.) TERHADAP JUMLAH ERITROSIT PADA TIKUS (Rattus Norvegicus) YANG DIINDUKSI GENTAMISIN DOSIS TOKSIK. Skripsi thesis, Universitas Airlangga.

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Abstract

The aims of this research was to determine the effect of leaves extract of sambiloto as a nephroprotector on renal function evaluated by Erythrocytes amount on white rat after gentamicin toxic dose induction. The effect of leaves extract of sambiloto was tested in 25 rats. Twenty five male white rat were randomly divided into five groups; K- as negative control was given carboxy methyl cellulosa in 15 days, P0 was given carboxyl methyl cellulosa in 15 days, P1, P2 and P3 were respectively given leaves extract of sambiloto with a dose of 177 mg / kg bw / day / po, 189 mg / kg bw / day / po, and 239.5 mg / kg bw / day / po for 15 days. On the 15 day of experimental, P0, P1, P2, P3 was given 200 mg/kg bw of gentamicin. Gentamicin solutions on P0, P1, P2 and P3 treated through intramuscular injection. After 24 hours of gentamicin induced, blood sample was taken through intracardiac, then Erythrocytes amount test using analysis of variance (ANOVA). Based on the result of the analysis of variance (ANOVA) range test obtine average value and standart defiation after in the logaritma of 6.84 / (K-), 5.67 / (P0), 6.26 (P1), 6.29 / (P2), 6.52 (P3) is showed signifikan difference (p < 0,05). In conclusion, leaves extract of sambiloto ( Andrographis paniculata ) can stabilize the number of erythrocytes in white rats ( Rattus norvegicus ) after administration of the doses of gentamicin

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