Wahjuni, Retno Sri and Sabdoningrum, Emy Koestanti and Hidanah, Sri (2017) Immunomodulation Effect of Meniran (Phyllanthus Niruri Linn) on blood profile of Broiler Chickens with enterotoxin of antibiotic resistant Escherichia coli. Proceeding The 1st International Conference Postgraduate School. Advances in Social Science, Education and Humanities Research (ASSEHR), 98. pp. 311-313. ISSN 2352-5398

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Abstract

The use of antibiotics against Escherichia coli on broiler chicken should be re-evaluated because antibioticresistant Escherichia coli has been found. Meniran ( Phyllanthus niruri Linn ) is a plant that can be used as an alternative to the prevention and treatment of the diseases caused by Escherichia coli enterotoxin. In this study, 28-day old broiler chickens were divided into six groups. Group 1 was a positive control group infected by Escherichia coli while group 2 was a negative control group without infection. The next group (group 3) were infected with Escherichia coli and given an extract of meniran of several different doses including 20%, 25%, and 30%, respectively. The last group used only an antibiotic as a treatment. Blood collection was conducted five days after treatment. The data obtained was analysed using ANOVA and was continued by a Duncan Multiple Range Test. The results showed that there was a significant difference in the immunomodulation activity in the group with 30% doses of meniran extract. The 30% doses of meniran extract were able to decrease the number of lymphocytes in the blood. In conclusion, a 30% concentration of meniran extract (Phyllanthus niruri L.) can decrease the number of lymphocytes in the blood of broiler chicken infected with the enterotoxin of antibioticsresistant Escherichia coli. Keywords: Immunomodulation, Phyllanthus niruri Linn.extract, Broiler, Escherichia coli

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