Nizar Al Rhaazi, NIM011511133120 (2018) KARAKTERISTIK KANKER OVARIUM TIPE EPITEL YANG MENJALANI OPERASI DI DEPARTEMEN OBSTETRI DAN GINEKOLOGI RSUD DR. SOETOMO TAHUN 2015. Other thesis, Fakultas Kedokteran.

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Abstract

Latar belakang: Kanker ovarium adalah salah satu penyakit yang berbahaya bagi wanita dengan angka mortalitas kelima dari seluruh kanker. Di Indonesia, hasil luaran operasi dan karakteristik kanker ovarium epitelial masih sedikit diteliti. Penelitian retrospektif ini bertujuan untuk mencari karakteristik klinis dan hasil luaran operasi pasien kanker ovarium di RSUD Dr. Soetomo Surabaya, Jawa Timur. Metode: Penelitian ini merupakan penelitian deskriptif secara retrospektif dengan tujuan untuk mengetahui hasil luaran operasi pasien kanker ovarium dengan melihat rekam medis pasien kanker ovarium Poli Onkologi Kandungan RSUD Dr. Soetomo Surabaya. Hasil: Penelitian ini terdiri dari 42 pasien, yaitu 31 pasien kanker ovarium tipe epitel stadium III & IV dan 11 pasien kanker ovarium tipe epitel stadium I & II. range umur wanita 40-49 tahun dengan rata-rata 44 dan median 45. Jenis histologis pasien kanker ovarium tipe epitel yang paling umum adalah Serous 25%. Stadium III & IV terlihat pada 75% pasien diikuti oleh 25% tahap I & II. Primary Debulking Surgery dilakukan 100% pada stadium I & II. Pada tahap III & IV perawatan pasien kanker ovarium tipe epitel Primary Debulking Surgery 68% dan Interval Debulking Surgery 32%. Residu tumor <2 cm pada stadium I & II 91%. Sementara itu, pada tumor residu EOC Tahap III & IV kurang dari 2 cm hanya 53%. Paclitaxel-Carboplatin adalah rejimen kemoterapi lini pertama, kepatuhan pasien baik sekitar 67% pada semua stadium. Kesimpulan: Penelitian ini menunjukan bahwa kanker ovarium tipe epitel paling sering ditemui pada stadium akhir, range umur 40-49, menjalani tipe operasi Primary Debulking Surgery dan paling banyak menghasilkan residu tumor < 2 cm. Berdasarkan penelitian ini kami menemukan bahwa residu tumor < 2 cm adalah prognosis faktor yang baik dan kepatuhan kemoterapi dapat menaikan free progression interval. --------------------------------------------------------- ntroduction: Ovarian cancer is one of the most threatening disease among women with gynecological malignancies in the world and it is the fifth most common type of cancer. In Indonesia, the number of survival rate and characteristics epithelial ovarian cancer are typically unreported. This retrospective study was aim to search clinical characteristic and treatment outcomes of Epithelial Ovarian Cancer (EOC) patients in Dr. Soetomo General Hospital Surabaya, East Java Methods: we held a descriptive non experimental study and reviewed the patient medical records who suffered from epithelial ovarian cancer in RSUD Dr. Soetomo Surabaya with history of surgical staging. The purpose of this study is to find out the outcomes of the EOC patients who underwent the surgical staging Results: The study included 42 patients, consist of 31 EOC stage III & IV and 11 EOC stage I & II. The majority age range is woman 40-49 years old with mean 44 and median 45. The most common histological types of EOC was Serous 25%. Stage III & IV were seen in 75% EOC patients followed by 25 % stage I & II. Primary debulking surgery was initial treatment in EOC, type of staging that given to stage I&II was primary debulking. In Stage III&IV EOC patients treatment was also primary debulking surgery 68% and interval debulking surgery 32%. Residual tumor less than 2 cm in stage I&II was 91%. Meanwhile, in EOC Stage III & IV residual tumor less than 2 cm was only 53%. Paclitaxel-Carboplatin was the regimens of first line chemotherapy, patients compliance was good approximately 67%. Conclusions: This study revealed that EOC occurred mostly in high stage, age group 40-49, underwent PDS and most frequent diameter residual group is < 2 cm. From the research held in Dr Soetomo, we conclude that there is a correlation between residual tumor diameter and chemotherapy compliance, residual tumor <2cm is good prognostic and chemotherapy compliance could help increasing progression free interval.

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