EFIN WINDI DAYANTI, 061511535010 (2019) EFEKTIVITAS KITOSAN DARI LIMBAH KULIT UDANG TERHADAP ANGIOGENESIS DALAM PENYEMBUHAN LUKA EKSISI PADA TIKUS PUTIH (Rattus norvegicus) JANTAN. Skripsi thesis, Universitas Airlangga.

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Abstract

Excision wound is caused by sharp objects cutting the tissues (Partogi, 2008). Chitosan is substance that capable to increase wound healing, that is in the process of angiogenesis. The objective of this study was to determine the effectiveness of chitosan ointment made of shrimp skin waste against angiogenesis in excision wound healing. Twenty male white rats were divided into five groups, namely K+ excision wounds with povidone iodine, K- excision wounds with ointment without chitosan, P1 excision wound with 1.5% chitosan ointment, P2 excision wounds with 2.5% ointment and P3 excision wounds with 5% ointment. Therapy was administered once a day for seven days. The results of the average data on the number of new blood vessels were analyzed using Anova test which showed a significant difference (p <0.05) and then analyzed using LSD (Least Significant Differences) test. P1 and P2 groups did not show significant differences, but were significantly different from K+, K- and P3 groups. From the results, it can be concluded that chitosan is effective in increasing the number of new blood vessels in the excision wound healing process.

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