Supriyadi and Trijono Karmawan Sukana Prija and Retno Pudji Rahayu (2018) Radioadaptation Response of Parotid Salivary Glands Acinar Cells Induced the Low Dose of X-Ray Radiation from Skull Radiography and Then Challenged The Therapy Dose of Gamma-Ray Radiation: The Measurements of Hsp70 Expression, SOD2 Activation, and MDA Concentration. Journal of International Dental and Medical Research, 11 (3). pp. 804-809. ISSN 1309-100X,

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Abstract

The aim of this study was to measure the Hsp70 expression, SOD2 activity and MDA concentration on radioadaptation response of parotid saliva glands acinar cells induced the low-dose of X-ray radiation from Skull Radiography. This research involved 24 males Rattus Norvegicus, wistar strains divided into 4 groups: normal control, positive control, adaptation of A (single of X-ray exposure from Skull Radiography), and an adaptation of B (chronic of X-ray exposure from Skull Radiography). The Challenge radiation exposure was performed 5 hours after adaptive radiation. The radiation was directed at the dorsal of animal’s head. The animal research to be sacrificed 24 hours after challenge radiation exposure, and soon the parotid tissue was taken. Furthermore, tissue processing was performed for histopathological specimens. Hsp70 expression, SOD2 activity, and MDA concentration were measured using immunohistochemical techniques. The data were analyzed by one way ANOVA test (α = 0,05) using SPPS software version 21. The results showed that there were significant differences for Hsp70 expression, SOD2 activity and MDA concentration of parotid salivary glands acinar cells among 4 groups. The low-dose of X-ray radiation from Skull Radiography may induce radioadaptation response in acinar cells of parotid salivary glands.

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