Soegeng Wahluyo and Prawati Nuraini and Retno Pudji Rahayu and Kun Ismiyatin and Retno Handayani and Soetjipto (2017) The Effect of NaF on the Existence of Ameloblasts and the Change of Tooth Dimension. Journal of International Dental Medical Research, 10 (1). pp. 139-144. ISSN 1309 – 100X

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Abstract

Ameloblasts cell which is very sensitive to the influence of internal and external factors. One external factor is the effect of fluoride elements that are able to affect the integrity of the ameloblasts cells and structure as well as the dimensions of the tooth enamel. This study seeks to analyze the effect of sodium fluoride exposure on the existence of tooth ameloblasts cells using indicators such as caspase-3, B-cel lymphoma 2 (Bcl-2), the distance between ameloblasts cells, as well as changes in the size or teeth dimension. Adult male healthy rats were used to experiment models, control (sterile distilled water treated), treatment group in to fluoride treated. The difference test on Bcl-2 and Caspase-3 between the control and the treatment groups showed different results (p <0.05). Similarly, the difference test on the distance between the ameloblasts cells as well as that on the dimensional change in both groups indicated significantly different results (p <0.05). These results suggest that the induction of sodium fluoride showed the increase of Caspase-3 protein expression, the decrease of Bcl-2 expression, and the widening of the distance between ameloblasts cells, and the changes in the size or teeth dimension.

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