Hanik Badriyah Hidayati and Paulus Sugianto and Junaidi Khotib, NIDN. 0022107001 and Chrismawan Ardianto, NIDN. 0029028403 and Kuntoro and Mohammad Hasan Machfoed (2018) Pengukuran Tingkah Laku pada Model Nyeri Neuropatik Perifer: Tikus dengan CCI (Chronic Constriction Injury). Majalah Kedokteran Neuro-Sains, 35 (3). pp. 209-214. ISSN 0216-6402

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Abstract

Neuropathic pain occurs in 20% of patients with chronic pain. This mainly due to the lack of effective treatment and the presence of drug’s side effects. Animal models have been broadly utilized in validating the therapeutic target and the development of analgesic drugs. Chronic constriction injury (CCI) is a model of peripheral neuropathic pain characterized by allodynia and hyperalgesia. Chronic constriction injury model is produced by loose ligation of the sciatic nerve resulting in nerve damage, thus sensitizes and lowers pain threshold. The pain threshold test is performed by providing a pressure and thermal sensory stimulus that results in observable withdrawal behavior. This article discusses several methods in assessing pain-related behavior on the CCI neuropathic pain model.

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