Rahayu Setiyaningsih, 091170101 and Hening Laswati Putra, NIDN. 8858800016 and Ferdiansyah Mahyudin, NIDN. 8890010016 and Fedik Abdul Rantam, NIDN. 0010035907 and Aulanni'am (2017) Foam-Cell Signified Blood Vessel Endhotel Repair and Histopatology of Abdominal Aorta through Stem Cell Allogenous Therapy to Rats (Rattus norvegicus) with Atherosclerosis. International Journal of Pharmaceutical and Clinical Research, 9 (1). pp. 91-95. ISSN 0975-1556

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Abstract

Atherosclerosis is a chronic inflammation process of endothel cell layer of blood vessels which is initiated by the disfunction of the endothel. This research aimed at understanding the repairment mechanism of the function of endothel in cardiac blood vessels with ateroskleroris case after being given medium-intenity physical exercises, mesenchymal stem cell and combination of the medium intensity physical exercises and mesenchymal stem cell by lookin into the foam cell of abdominal aorta. This research employed true experimental research design with post test only control group design. The sample of this reseach were 24 male Wistar rats (Rattus norvegicus) furrow that were controlled its homogeneity using inclusive criteria; confirming ateroclerosis, 20 week age, weight ranged from 180-200 gram, inhybrid, and healthy that were indicated by good desire for food and behaved normally. The Rattus norvegicus which fulfilled the inclusive criteria were divided into three groups which first group was the control group (atheroscleoris rats). The second group was ateroclerosis rats and received regular medium-intensity physical exercises. The third group atherosclerosis which received combination of regular medium-intensity physical exercises and received mesenchymal stem cell. The result of manova test showed value p < 0.001 which indicated the existence of different foam cell found in the control group, exercise group, stem cell group and combined exercise and stem cell group. It can be concluded that attempt to decrease the risk factor of aterosclerosis is one of the ways to protect the endothel of the blood vessels. Deep understanding on this mechanism is expected to give new insights to do preventive action and treatments toward ateroclerosis by combination theraphy of regular medium-intensity physical exercises and received mesenchymal stem cell.

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