Imam Susilo and Elvina Mulyasari S and Chrismawan Ardianto, NIDN. 0029028403 and Junaidi Khotib, NIDN0022107001 (2009) Effect of Vanadyl Sulfate in Beta Pancreas Celis of Mice With Diabetes Mellitus. In: Second Collaborative Conference UNAIR-USM, 10-11 Februari 2009, Universitas Airlangga. (Unpublished)

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Abstract

The aim of this study is to examine biochemical and histological perspective, whether vanadyl sulfate has an effect on the beta pancreas cells of streptozotocininduced diabetic mice.The diabetic model was elicited by twice intraperitoneal injection of streptozotocin 100 mg/kg followed with 50mg/kg on day 14. Diabetes occurred on day 21 after streptozotocin injection and glucose level raised from 162,2 ± 21,3 mg/dL to 184,3 ± 27,1. After the treatment of vanadyl sulfate once a day for 7 days, blood glucose level were reduce significantly (5 mg/kg, p = 0,013; 30 mg/kg, p <0,001). On day 28 pancreas tissue harvest from normal mice, streptozotocininduced diabetic mice and diabetic mice given vanadyl sulfate. Tissue sections were stained using hematoxylin-eosin and aldehid fuschin. In pancreatic islet of diabetic group, a damage islet, decline islet size, degenerative and apoptosis beta pancreas cell was observed. While pancreatic of diabetic group given vanadyl sulfate showed amelioration in islet cell. Apoptosis beta cells were reduce, andproliferative cells were appear. Islet become intact and the size was increase closed on normal mice.

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