Helmy Yusuf, NIDN. 0015077901 (2014) EFFECT OF TREHALOSE ON THERMAL PROPERTIES OF PHOSPHOLIPID AND TPGS MIXTURES. In: Proceeding the 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Faculty of Pharmacy Universitas Airlangga, Surabaya, pp. 124-126. ISBN 978-602-72333-0-0

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Abstract

The freeze-dried liposome as immunological adjuvant/vaccine delivery systems is one of recent articular interest in the area. DDA is one of the articular interests in immunological adjuvant materials. DDA is a quarterammonium compound with long chain alkyl groups that contribute to its lipophilic properties. It also comprises dimethylammounium headgroup (positively charged) that is attached to the two carbon alkyl chains and contributes to its hydrophilic properties. Both properties of DDA make it suitable for such application in the preparation of cationic liposomes [1-3]. However, DDA liposomes have some drawbacks such as physical instability, as they are easily aggregate in presence of small amounts of salt or even in pure water [7, 8]. As water has been considered as an ideal dispersion medium, then improving DDA formulations is still challenging. This project focuses on the development of potential new formulations of lyophilized liposomes as immunological adjuvant in vaccine delivery system and in-vestigations based on their physicochemical characteristics. Lyoprotectant, i.e. trehalose and membrane stabilizer, i.e. TPGS (D-alpha tocopherol polyethylene glycol 1000 succinate) were used in the freeze-dried liposome. formulations.

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