Rahmi Annisa and Dewi Melani Hariyadi and Esti Hendradi (2018) Evaluation of the Physical Stability of Nanostructured Lipid Carrier (NLC) Meloxicam Before and After Strorage 40 Days. International Journal of Drug Delivery Technology, 8 (2). pp. 107-109. ISSN 0975 4415

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Abstract

Objective: The aims this study was to determine the effect of lipid ratio Monostearin and Miglyol 808 roomates gives the physical stability after storage 40 days. Methods: The NLC making was done by using emulsification method in the formation of NLC meloxicam, 3 different lipid ratios were used, including ratios of 6: 4, 7: 3, 8: 2. Results: NLC meloxicam physical stability of the pH, viscosity, particle size, particle morphology and entrapment efficiency. NLC meloxicam belongs to semisolid preparations with pH value range of 5.72-5.87. Increasing viscosity of NLC system is caused by the increase of solid lipid. The measurement results of particle size of three different lipid formulas indicated that the lipid particle size was <1000 nm. Entrapment efficiency test of all NLC-lipid compositions revealed quite high result (>80%). Conclusion: The system uses lipid monostearin NLC meloxicam and Miglyol 808 at a ratio of 8: 2 is the most optimal combination shows physical stability after storage 40 days.

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