Esti Hendradi and Isnaeni and Raudatul Patimah (2018) The Performance of Nanostructured Lipid Carrier (NLC) Incorporated Transdermal Patch Coenzyme Q10: Effect of Lipid Ratio as Drug Reservoir and HPMC 606 as Rate Controlling Membrane. International Journal of Pharma Research and Health Sciences, 6 (5). pp. 2796-2800. ISSN 2348-6465

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Abstract

Coenzyme Q10 is a strong antioxidant. Coenzyme Q10 can improve cellular dynamics inhuman body and playan effective role in preventing skin aging, keratinization and DNAoxidative. Coenzyme Q10 NLC system with different lipid ratio 70:30 (cetyl palmitate andalpha tocopheryl acetate) used as drug reservoir dan hydroxypropyl methylcellulose 606(HPMC 606) as rate controlling membrane. NLC coenzyme Q10 as drug reservoir wereprepared using high shear homogenization method. Transdermal patch was usingmembranetype with HPMC 606 as rate controlling membrane. This research was investigatethe effect of concentration of HPMC 10%, 15% and 20% on the characteristics coenzyme Q10transdermal patch. The prepared transdermal patches were evaluated for thickness, weightvariation, moisture content, drug content and drug homogenity which were found to 1.98 ±0.003 mm, 1.422 ± 0.003 g, 8.441 ± 0.077 %, 96.90± 0.92 and 97.75 ± 1.78 %, respectively.All independent variables had no significant effect on the dependent variables (p-values>0.05) usingone way ANOVA, except the weight and moisture content patches.

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