P. Christanto and Isnaeni and Andang Miatmoko and Esti Hendradi (2018) Transdermal patch loading diclofenac sodium for anti inflammation therapy using rat paw oedema model. In: Unity in Diversity and the Standardisation of Clinical Pharmacy Services : Proceedings of the 17th Asian Conference on Clinical Pharmacy (ACCP 2017), July 28-30, 2017. CRC Press, London, pp. 10-18. ISBN 978-1-138-08172-7

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Abstract

The anti-inflammatory effect of transdermal delivery of a diclofenac sodium patch was evaluated. The patch matrix consists of ethyl cellulose N-20 and polyvinyl pyrrolidone K-30 to control the drug release. In this study, the patches were prepared with ethyl cellulose N-20 (EC-N20) and polyvinylpyrrolidone K-30 (PVP K-30) at weight ratio of 6:4 and 7:3 for EC/PVP-6/4 and EC/PVP-7/3 patches, respectively. The anti-inflammatory effect was determined by evaluating the swelling of rat’s paw oedema that was induced with 1% carrageenan suspension. The results showed that the high concentration of PVP K-30 resulted in less rigid patch with pore structures. In addition, it improved the antiinflammatory effect of diclofenac sodium resulted in higher efficacy of EC/PVP-6/4 than that of EC/PVP-7/3. There were no significant differences on drug stability observed for both formulations. It can be concluded that controlling diclofenac sodium released from patch using PVP K-30 could give benefits for anti-inflammation therapy.

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