Sri Puji Astuti Wahyuningsih, NIDN. 0021026604 and Sugiharto, NIDN. 0001037003 and Nurul Wiqoyah, NIDN. 0006096404 and Zakiyatun Nuha (2015) Polysaccharide Krestin Activity of Coriolus versicolor Extract on Interleukin-12 Level of Musmuculus Exposed to Mycobacterium tuberculosis. In: Proceeding 5 th International Conference and Workshop on Basic and Applied Sciences (5th ICOWOBAS): Science, Technology,and Innovation for Sustainable Development. Kampus C UNAIR, Surabaya, pp. 172-176. ISBN 978-979-19096-2-4

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Abstract

Abstract. This study aimed to determine the effect of polysaccharide krestin (PSK) of Coriolus versicolor‘s extract on IL-12 levels in the Mus musculus‘s blood serum that had been exposed by Mycobacterium tuberculosis. This study used a completely randomized design were divided into six treatment groups. They were K (control group without treatment), K+ (positive control by providing PSK), K- (negative control with exposed M. tuberculosis), P1 (treatment using PSK before exposured by M. tuberculosis, P2 (treatment using PSK after exposured by M. tuberculosis), and P3 (treatment using PSK before and after exposured by M. tuberculosis). PSK given concentration was 200 mg/kg bw, while the number of bacteria for exposure was 0.25 Mc Farland with double exposure. Each treatment there were four replicates. Blood serum of mice were isolated and measured levels of IL-12 by ELISA kit. Data analysis used Brown Forsythe test. The results showed that the highest levels of IL-4 was K-. PSK administration in the treatment of P1, P2, and P3 showed the levels of IL-12 not significant with the K and K +. Conclusion of the study was the treatment using PSK had no effect on the level of IL-12 in Mus muculus exposed by M. tuberculosis

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