Dita Nur Kurnia Putri, 061511133247 (2019) POTENSI NANOPARTIKEL EKSTRAK DAUN JUWET (Syzygium cumini ) SEBAGAI TERAPI ADJUVAN BERDASARKAN GAMBARAN HISTOPATOLOGI CEREBELLUM OTAK MENCIT (Mus musculus) YANG DIINFEKSI Plasmodium berghei. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This study is aimed to know the potential of juwet leaf extract as adjuvant therapy on brain of mice (Mus musculus) which infected by Plasmodium berghei. Thirty mice divided into six groups namely K0 as negative control group without infection, K+ as positive control infected by Plasmodium berghei 1x105 in 0,2 ml without therapy, K1 infected and treated by chloroquine, K2 infected and treated by juwet leaves extract, P1 infected and treated by nanoparticles juwet leaves extract and P2 which infected and treated by chloroquine with nanoparticles juwet leaves extract. The data were analyzed by Kruskal Wallis using SPSS and followed with Mann-Whitney test. This research result showed there was significant difference (p < 0.05) between K1 and P2, but did not showed significant difference (p > 0.05) with K+, K2 and P1. The results showed nanoparticles juwet leaves (Syzygium cumini) extract as adjuvant therapy has an effect on histopathological features of mice’s cerebellum infected by Plasmodium berghei.

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