Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco) Repository

Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco)

Tristiana Erawati and Widji Soeratri and Noorma Rosita (2018) Skin Penetration of Ubiquinone (Co-Q10) In Nanoemulsion Delivery System Using Virgin Cocunut Oil (Vco). International Journal of Drug Delivery Technology, 8 (2). pp. 77-79. ISSN 0975 4415

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Abstract

Ubiquinone (co-Q10) is a topical anti-aging with low solubility in water, so its penetration into the skin is also low. To increase its penetration ubiquinone (co-Q10) was loaded in the nanoemulsion delivery system using virgin coconut oil (VCO) as oil phase. Ubiquinone (co-Q10) in nanoemulsion formula consists of; ubiquinone (co-Q10), Tween 80, Span 80, ethanol 96%, VCO and acetate buffer solution pH 4.2 ± 0.5 with concentration; 1%; 18.66%; 1.92%; 3.42%; up to 100%, respectively. The characteristics of ubiquinone (co-Q10) nanoemulsion were observed in terms of droplet morphology by transmission electron microscope (TEM) and droplet size by particle analyzer, the pH and viscosity value. The ubiquinone (co-Q10) penetration test in the nanoemulsion system was compared with the emulsion on the rat skin. Result of this research showed the droplet morphology of ubiquinone (co-Q10) in nanoemulsion was spherical. The droplet size was 93.2 ± 2.78 nm. The pH value was 4.12 ± 0.02, and the viscosity was 8.5 cPas. Penetrasi of ubiquinone (co-Q10) in nanoemulsion was deeper (269 ± 48.12 and 993 ± 36.49 μm) than in emulsion (26.33 ± 6.43 and 110.33 ± 9.124 μm), after 2 and 6 hours sample application.

Item Type:

Article

Uncontrolled Keywords:

Nanoemulsion, Skin Penetration, Ubiquinone (co-Q10), Virgin Coconut Oil (VCO).

Subjects:

R Medicine
R Medicine > RS Pharmacy and materia medica

Divisions:

05. Fakultas Farmasi

Creators:

Creators	NIM
Tristiana Erawati	NIDN0018055803
Widji Soeratri	NIDN0006105103
Noorma Rosita	NIDN0025126506

Depositing User:

Mr M. Fuad Sofyan

Date Deposited:

11 Oct 2019 08:33

Last Modified:

29 Sep 2021 05:20

URI:

http://repository.unair.ac.id/id/eprint/87915

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