Tristiana Erawati, - and Dewi Melani Hariyadi, - and Noorma Rosita, - and Tutiek Purwanti, - (2019) The Anti-inflammatory Activity of p-methoxycinnamic acid (PMCA) in the Nanostructured lipid carrier (NLC) system using combinations of solid lipid, beeswax-oleum cacao and liquid lipid, Virgin Coconut oil (VCO). Research Journal of Pharmacy and Technology, 12 (8). pp. 1-7. ISSN 0974-3618

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Abstract

Objective: The nanostructured lipid carrier (NLC) system used the combination of beeswax-oleum caco and virgin coconut oil (VCO) in this study, it was the development of nanoemulsion (NE) and solid lipid nanoparticle (SLN) delivery systems, which are used as nano-carriers of p-methoxycinnamic acid (PMCA). PMCA a secunder metabolite of champheria galanga has antiinflamatory effect which is difficult to dissolve in water. Several combinations of solid lipids (beeswax-oleum cacao) and liquid lipids (VCO) were prepared, namely F I (60:40); F II (70:30); and F III (80:20) in the NLC system. Material and Method: The NLC-PMCA system was prepared by the high shear homogenization method, then characterized and subjected to antiinflammatory activity tests compared with nanoemulsion and solid lipid nanoparticle (SLN). The results of the research: The increasing concentration of VCO in the NLC-PMCA system resulted in lower viscosity, and greater entrapment efficiency, namely in the NLC-PMCA system with a combination of beeswax-oleum cacao and VCO of 60:40. NLC-PMCA with the combination of beeswax-oleum cacao and VCO of 60:40 (F I) has particle size (236.00 ± 17.15 nm) smaller than SLN-PMCA (665.60 ± 72.59 nm) but biger than NE-PMCA (29.27 ± 1.85 nm). Occlucivity of F I NLC-PMCA (41.50 ± 4.00 %) higher than SLN-PMCA (33.52 ± 3.65 %) and NE-PMCA (33.52 ± 3.65 %). PMCA in NLC, SLN and NE has the same anti-inflammatory activity based on the observations of the PMN cells number in ear skin mice with edema. Conclusion: The NLC-PMCA with the combination of beeswax-oleum cacao and VCO of 60:40 was the best formula.

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