Noorma Rosita and Widji Soeratri and Tristiana Erawati and Ayunanda and Wakhida Fitriyani (2014) In Vitro Effectivity Para Methoxy Cinnamate Acid (PMCA) In Solid Lipid Nanostructure (SLN) System Using Cetyl Alcohol As Lipid Formulated In HPC-H Gel Base. World Journal of Pharmaceutical Research, 3 (5). pp. 58-65. ISSN 2277 – 7105

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Abstract

Introduction: In vitro effectivity of solid lipid nanostructure (SLN) as carrier system has been studied on para methoxy cinnamate acid (PMCA) as a means of releasing PMCA and penetrating to prolong antiinflamasi preparation. Methods: SLN was made using cetyl alcohol as lipid and Tween 80 as stabilizer, produced by high shear homogenisatian (HPH) method. SLN was then formulated in HPC-H 3% gel base. Release study were conducted in phosphat buffer medium pH 7,4±0,05 at 32°C and stirred at 100 rpm using apparatus type 5-paddle overdisk. Penetration study were investigated in same medium at 37°C by using Wistar male rat skin 2-3 month age and weight 115-180 gram, as a membrane. Results: Both PMCA released and penetrated PMCA concentration was measured spectrophotometrically at 286 nm as λ max. Spherical SLNAPMS with particle size of 26-265 nm and 64.86% drug entrapment were produced. PMCASLN had pH 3,79±0,05 in HPC-H gel. In vitro release and penetration study were investigated using PMCA only (F-I), PMCA in macroemulsion (F-II) and PMCA-SLN (F-III) which was formulated in gel HPC-H. PMCA which was dispersed in gel had largest release and higher penetration, followed by PMCA in macroemulsion and lastly PMCA-SLN. Release flux for formula PMCA only, PMCA in Macroemulsion and PMCA-SLN were 62,6969 ± 1,33; 48,7949 ± 1,07 and 27,4652 ±0,84 µg/cm2/second-½ , whereas penteration flux were 0,3065 ± 0,1470; 0,1795 ± 0,0634 and 0,2925 ± 0,0996 µg/cm2/second1 for formula I, II and III respectively. Conclusion: SLN system has been able to retard released and penetrated PMCA.

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