Tegar Gusta Rahmawan and Noorma Rosita and Tristiana Erawati (2012) Characterisation Of Solid Lipid Nanoparticles P-Methoxycinnamic Acid (SLN-PMCA) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol. PharmaScientia, 1 (1). pp. 23-29. ISSN 2302-0725

	Text (FULLTEXT) Artikel C-14.pdf Download (2MB)
	Text (PEER REVIEW) C-14 Reviewer.pdf Download (1MB)
	Text (ARTICLE (NR)) Artikel C-22.pdf Download (1MB)
	Text (PEER REVIEW (NR)) Validasi C-22.pdf Download (1MB)

Abstract

Solid lipid nanoparticles (SLN) had been increasingly investigated as a new drug delivery system. SLN had several benefits as a topical drug carrier. p-Methoxycinnamic acid (PMCA) was a hidrolized product of ethyl-p-methoxycinnamic (EPMC), which is the highest component of Kaempferia Galanga extract, was proposed to have an antinociceptive activity. The aim of this study is to identify the characteristics of SLN-PMCA formulated through different lipid matrices, such as stearic acid and cetyl alcohol. SLN was prepared using high shear homogenization method at 25000 rpm for 8 minutes. The previous observed formula (Misra, et al, 2004) was used as the reference formula with few modifications. SLN-PMCA product were characterized for entrapment efficiency, morphology and particle sized. The result showed cetyl alcohol had higher entrapment efficiency (mean 68,54%) and smaller particle size (mean 119,25 nm) than stearic acid contained formula. The Transmission Electron Microscope (TEM) result showed spherical particles for cetyl alcohol while stearic acid was oval-shaped.

Actions (login required)

View Item