Widji Soeratri and Tristiana Erawati and Noorma Rosita and Fahriyatul Wahyuni (2009) The Influence of Olive Oil Addition on Increasing Arbutin Penetration in the Carbomer 940 Gel (Observation on Inhibition of Enzym Tyrosinase Activity). In: Proceeding The 1st International Conference on Pharmacy and Advanced Pharmaceutical Sciences. Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, pp. 78-81. ISBN 978-979-95107-7-8

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Abstract

The aim of this study was to investigate the influence of olive oil addition on the increasing of arbutin penetrations in the Carbomer-940's gel; it was observed on inhibition of enzyme tyrosinase activity. High hydrophilicity of arbutin (log P value, -1.35) makes it difficult to permeate through the skin and reach site of action. Olive oil addition was expected to increase the arbutin penetrations. Percent inhibition of tyrosinase by arbutin was determined by observing absorption value of Dopachrome (in intermediate product of melanin formation) using spectrophotometer. The result of this study, percent inhibition of the formula control, 1, 2 and 3 were 21.79; 24.24; 21.79 and 35.60% respectively. The processing data was using the statistic programmed of SPSS 12.0 with one way ANOVA method obtained the result there was significant difference from percent inhibition in one of formula. Conclusion from this study was olive oil addition 7% could increase of arbutin penetrations and increase the inhibition of enzyme tyrosinase activity.

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