Tristiana Erawati and Anneke Indraswari P and Nanda Ghernasih Navy Caristya and Noorma Rosita and Suwaldi Martodihardjo and Widji Soeratri (2014) Anti Inflammatory Activity of Para Methoxy Cinnamic Acid (PMCA) on Nanoemulsion Using Sybean Oil. In: Proceeding The 1st International Conference on Pharmaceutics & Pharmaceutical Sciences. Fakultas Farmasi Universitas Airlangga, Surabaya, pp. 266-279. ISBN 978-602-72333-0-0

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Abstract

Inflammation is a protective mechanism of the local microcirculation to tissue injuries caused by physical trauma, stimulation by hazardous chemicals, heat, antigen-antibody reaction and the effect of microbial.[2] It is known to be involved in the inflammatory reactions such as release of histamine, bradykinin, pros­taglandins, fluid cell migration, extravasations, tissue break down and repair which are aimed at host defense and usually activated in most disease conditions. Para methoxy cinnamic acid (PMCA) known has topical anti-inflam­matory effect but only 0.64 compare with Na-diclophenac.[4] Its cause PMCA is a poorly soluble drug substance (BCS II), the solubility in acetate buffer pH 4.2 ± 0.2 was 70.04 ± 0.66 mg/liter.[3] So In this study to increase the solubility PMCA loaded in nanoemulsion using soybean oil. And then the anti-inflammatory activity of PMCA in nanoemulsion was mea­sured by the release rate, penetration rate through rat skin using Franz diffusion cell and histological test on mice's ear skin.

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