TRI DANANG KURNIAWAN, 051514153022 (2019) KARAKTERISTIK, PELEPASAN DAN AKTIVITAS ANTIBAKTERI MIKROSFER SIPROFLOKSASIN HCl-Ca ALGINAT DENGAN TEKNIK AEROSOLISASI. Thesis thesis, Universitas Airlangga.
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Abstract
Drug delivery system through the lung is an alternative delivery to overvcome oral and parenteral delivery problems. The drug does not experience first past metabolism in the liver, high bioavailability, low side effect, and the right dose to be delivered to the target. To efficiently deposit the lungs, particles must have a size of 1-5 μm. Ciprofloxacin HCl is an effective broad spectrum antibiotic which was formulated into microspheres. The purpose was to determine the effect of alginate polymer concentration and CaCl2 concentration on the characteristics, release and antibacterial activity. Microspheres were produced by ionotropic gelation method with aerosolization technique. The results showed spherical characteristics microspheres, with particle size of less than 5μm, moisture content of less than 10%, yield was between 75.62 ± 4.47% to 79.40 ± 3.19%, drug loading and entrapment efficiency was range of 2.82 ± 0.21% to 4.13 ± 0.30% and 30.05 ± 2.37% to 74.53 ± 5.48%. F3 was the optimum formula. For 24 hours, the ciprofloxacin released was in the range of 80-100% at pH 7.4. Drug release kinetic showed zero order kinetic with mechanism based on non-fickian diffusion, an increased concentration of alginate and CaCl2 showed a decrease in release rate. Both microspheres and released sample, antibacterial activity against Staphylococcus aureus and Escherichia coli was shown. Overall, ciprofloxacin HCl-alginate microspheres produced by ionotropic gelation method with aerosolization technique were highly recommended for pulmonary drug delivery.
| Item Type: | Thesis (Thesis) | |||||||||
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| Additional Information: | KKB KK-2 TF. 25-19 Kur k | |||||||||
| Uncontrolled Keywords: | Ciprofloxacin HCl, Microsphere, Alginate, Characterictic, Release, Antibacterial Activity. | |||||||||
| Subjects: | R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions | |||||||||
| Divisions: | 05. Fakultas Farmasi | |||||||||
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| Depositing User: | Tatik Poedjijarti | |||||||||
| Date Deposited: | 10 Oct 2019 03:04 | |||||||||
| Last Modified: | 10 Oct 2019 03:04 | |||||||||
| URI: | http://repository.unair.ac.id/id/eprint/88710 | |||||||||
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