RAMADHANA YOGA PRABAWA, 061411131150 (2019) THE EFFECT OF FOLIC ACID AS ADDITIONAL THERAPY OF SPIRAMYCINE ON PHYSICAL DEFECT RISK OF FOETUS TO Toxoplasma gondii – INFECTED PREGNANT MICE (Mus musculus). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This research aimed to investigate the effect of folic acid as additional therapy of spiramycine on physical defect risk of foetus to Toxoplasma gondii-infected pregnant mice (Mus musculus). Twenty pregnant female mice were divided into four groups as C -, C +, T1 and T2. C +, T1 and T2 were infected by Toxoplasma gondii. C – and C + administered orally 0.5 ml aquadest, T1 administered orally 130 mg/kg BW spiramycine and 0.052 μg/g BW folic acid and T2 administered orally 0.052 μg/g BW folic acid. Experimental groups received the treatments for 5 days, then mice of each groups were sacrified. Foetuses were dissected out for observation. The physical defects of foetuses were measured. The data physical defect of foetuses was presented. From this study, the physical defects of foetuses from the pregnant mice of T1 and T2 have difference compared with the controls. The result of this research is folic acid affects the physical defect risk of foetuses to Toxoplasma gondii-infected pregnant mice.

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