Ganeswara Muharam Hazmi Rezady and Hani Plumeriastuti and Rimayanti (2019) Pengaruh Ekstrak Daun Pare (Momordica charantia) Terhadap Folikel Ovarium Tikus (Rattus norvegicus) Dalam Kondisi Hyperglycemic. Jurnal Ovozoa, 8 (1). pp. 61-65. ISSN 2302-6464

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Abstract

The purpose of this study was to prove that the provision of pare leaf extract can reduce the process of follicular atrophy in the ovaries caused by hyperglycemic conditions. The total of this study was completed within 20 days, including the induction of Streptozotocin for 5 days, treatment for 14 days, and 1 day for ovarian collection. The K- group as a negative control without being induced by Streptozotocin and received no treatment. The K- group as a positive control was only induced by Streptozotocin at a dose of 55 mg / Kg BW and Dip without treatment. The Ti group was induced by Streptozotocin at doses of 55 mg / Kg BW and Di, and treated with pare leaves extract (Momordica charantia) at a dose of 1.26 ml / Kg BW. T2 group was induced by Streptozotocin with dose of 55 mg / Kg BW and Dyy and was treated with pare leaves extract (Momordica charantia) at a dose of 2.52 ml / Kg BW. Induction of Streptozotocin intraperitoneally and once-daily peroral treatment. The result showed that treatment group could make a significant difference with the positive control. Showing that amount of gap could make Momordica charantia to be alternative treatment for hyperglycemic condition. | Key word: Hyperglycemic, Follicular Atrophy, Streptozotocin, Momordica charantia

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