NI MADE DWI MARA WIDYANI NAYAKA, 050710169 (2012) KARAKTERISASI SEDIAAN DAN UJI PELEPASAN NATRIUM DIKLOFENAK DENGAN SISTEM SOLID LIPID ANOPARTICLES (SLN) DARI BASIS GEL CARBOMER 940 (Sistem SLN Natrium Diklofenak-Setil Alkohol-Tween 0-Propilen glikol). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

The present study was designed to determine characteristic and release of diclofenac sodium in solid lipid nanoparticles (SLN) system from Carbomer 940 gel bases preparation. The compositions of SLN are diclofenac sodium 1%, setil alcohol 10%, Tween 80 10% and propylene glycol 15%. There were two formulas in this study. Formula I was Carbomer gel with SLN components (without system) and formula II was Carbomer gel with SLN system. The result showed that SLN system didn’t have effect on consistency, color and odor, but it had effect on pH and spreadability. Data analyze showed that pH of formula I was 6,27 ± 0,07 and formula II was 6,44 ± 0,02. Drug release test was carried out with apparatus 5-paddle overdisk in phosphate buffer saline 7,4 ± 0,05, temperature 32oC, 100 rpm. The drug release rate (flux) of formula I and II were 43,5995 ± 1,0579 μg/cm2/min1/2 and 31,2418 ± 1,8026 μg/cm2/min1/2, respectively. The result was analyzed by statistic programmed of SPSS 16.0 using Independent-sample t test with degree of confident 95% (α = 0,05). Research result revealed that diclofenac sodium release from Carbomer gel with SLN system was lower than from Carbomer gel with SLN components (without system).

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