ANINDYA RAMADHANTI YUFINANDA, 051511133014 (2019) DISOLUSI KOMPLEKS INKLUSI ASAM p-METOKSISINAMAT (APMS) - β-SIKLODEKSTRIN (βCD) YANG DIBUAT DENGAN METODE CO-GRINDING. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

p-methoxycinnamic acid (pMCA) is a promising active compound which has antibacterial, anticancer and antiinflammation effects originally obtained from Kempferia galanga Linn. However, pMCA is poorly soluble in water (0,712 mg/mL water at 25˚C) which can affect to low bioavailability and onset of action of pMCA. Therefore, forming inclusion complex with β- cyclodextrin (βCD) was made to improve its solubility and dissolution. The pMCA-βCD inclusion complex formed when pMCA, as the guest compound, enters the βCD cavity as the host compound. The aim of this study is to investigate the dissolution profile of pMCA-βCD inclusion complex made using co-grinding method. The inclusion complex was made at 1:1 stoichiometry ratio using high energy ball mill for three hours. The size was measured using light microscopy and showed that inclusion complex has smaller size compared to both pMCA and pMCA-βCD physical mixture. The dissolution test was done using water with a pH of 6,5 ± 0,5 at 37±0,5˚C and performed with apparatus II (paddle) at 75 rpm for 60 minutes. pMCA was measured by Spectrophotometer UV – Vis at 285,8 nm. The dissolution profile showed that pMCA-βCD inclusion complex has higher dissolution rate and ED60 compared to both pMCA and pMCA-βCD physical mixture. The pMCA-βCD inclusion complex shows higher dissolution by 3.5 times compared to the pMCA.

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