PENGARUH PERBANDINGAN D-α- TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE DAN POLOKSAMER P84 TERHADAP KARAKTERISTIK FISIK DAN STABILITAS MISEL KOMBINASI (MIXED MICELLES) (Untuk Pengembangan Sistem Penghantaran Hesperetin)

ITSNA FADLILATUL ARIFAH, 051511133041 (2019) PENGARUH PERBANDINGAN D-α- TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE DAN POLOKSAMER P84 TERHADAP KARAKTERISTIK FISIK DAN STABILITAS MISEL KOMBINASI (MIXED MICELLES) (Untuk Pengembangan Sistem Penghantaran Hesperetin). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Hesperetin is a flavonoid compound of citrus fruit that has a wide pharmacological effects. Nevertheless, its poor solubility in water limits its use as a therapeutic molecule. Mixed micelles were developed to increase the solubility of hesperetin. Mixed micelle from combination of D-α- tocopheryl polyethylene glycol 1000 succinate (TPGS) and poloxamer P84 (P84) are known to have synergism effect to improve quality of micelle. This study was aimed to investigate the effect of different ratios TPGS:P84 on physical characteristic and stability of mixed micelle. The mixed micelles were prepared by thin film hydration method. Dynamic light scattering method showed that particle size of mixed micelle TPGS : P84 ratio 1 : 4 was bigger than the ratio 1:1 and 1:2. In general, particle size of mixed micelles were smaller compared to TPGS-only micelle. CMC value of mixed micelles TPGS:P84 was lower than CMC of TPGS and P84 only. Mixed micelles also exhibited greater encapsulation efficiency than TPGSonly micelle. The lowest CMC and the highest encapsulation efficiency was obtained in mixed micelles TPGS:P84 with ratio 1:4. Stability test by diluting micelle using phosphate buffer showed no precipitation of the mixed micelles. The physical stability of micelles under storage condition was observed at 25C for 7 days. TPGS-only micelle showed precipitation after 3 days storage but mixed micelles showed no precipitation. In conclusion, increasing amount of poloxamer P84 in mixed micelles could form bigger particle size, lower CMC, greater encapsulation efficiency and better stability.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F 21/19 Ari p
Uncontrolled Keywords: Mixed micelles, TPGS, poloxamer P84, hesperetin, physical characteristic, stability
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM
ITSNA FADLILATUL ARIFAH, 051511133041UNSPECIFIED
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorDr. Muh Agus Syamsur Rijal, M.Si., Apt., NIDN: '0006076805UNSPECIFIED
Depositing User: Dwi Marina
Date Deposited: 11 Nov 2019 02:55
Last Modified: 11 Nov 2019 02:55
URI: http://repository.unair.ac.id/id/eprint/90652
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