DEAVISCA REZANIA, 051511133182 (2019) OPTIMASI FORMULA EMULGEL MINYAK VIRGIN COCONUT OIL KELAPA KOPYOR (Cocos nucifera L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Propionibacterium acnes ATCC 11827. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Kopyor coconut is a coconut that has fruit flesh apart from its shell. Kopyor coconut has high lauric acid content in the flesh. Besides, kopyor coconut contains vitamin c and α-tocopherol as antioxidants. Kopyor coconut has high lauric acid content in the flesh. Based on research, lauric acid can fight Propionibacterium acnes bacteria more than benzoyl peroxide. To increase its acceptability as an anti-acne, VCO of kopyor coconut was made become emulgel. VCO concentration as the active ingredient used based on the MIC test is 20% and 30%. While the gelling agent chosen was Carbopol 940 with a concentration of 1% and 2%. The emulgel then undergoes test of physic characterization such as viscosity, pH, spreadability, particle size, particle size distribution, and zeta potensial. The emulgel was also tested for antibacterial activity against Propionibacterium acnes. Stability tests using method of thermal cycling with a temperature of 40oC and 4 oC respectively for 24 hours for 3 cycles. Through this test, the chosen formula was formula 4, that has good zeta potential, suitable with skin pH, has a good particle size and particle size distribution and has inhibitory effect on P.acnes bacteria.

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