FERRICO APRIL DWI PRAYITNO, 051511133164 (2019) VALIDASI METODE KLTKT-DENSITOMETRI UNTUK PENETAPAN KADAR CEMARAN CAMPURAN DIMETIL FTALAT DAN DI-2-(ETILHEKSIL) FTALAT PADA PRODUK DEODORAN PADAT. Skripsi thesis, Universitas Airlangga.

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Abstract

Dimethyl phthalate (DMP) and di-2-(ethylhexyl) phthalate (DEHP) are two types of derivatives of phthalic ester compounds used as plasticizers to increase the flexibility or elasticity of plastic materials which are usually used in dosage packages. Phthalate esters usually used as a solvent, retain perfume, and as a stabilizer of the perfume. This study aimed to determine levels of contamination of DMP and DEHP in solid deodorants. This method uses densitometric High Performance Thin Layer Chromatography (HPTLC). HPTLC Silica Gel 60F 254 was used as the stationary phase and n-hexane: ethyl acetate (8 : 2) was used as the mobile phase. Camag TLC Scanner 3 was used for analysis DMP and DEHP scanned at 280 nm wavelength. This method was validated in selectivity, linearity, accuracy and precision. The results were selective to separate DMP from other components in the deodorant matrix with a good resolution (Rs) ≥ 1.5. Calibration shows good linearity with r² = 0.9980 in the concentration range of 20-100 ppm for DMP and 200-1.000 ppm for DEHP. The detection limit was 0.74 ppm and the quantification limit was 2.46 ppm for DMP, the detection limit was 4.05 ppm and the quantification limit was 13.51 ppm for DEHP. The accuracy method of DMP was 99.28 ± 1.48% while DEHP was 101.17 ± 2.4% and relative standard deviation (% RSD) of precision method was 3.96% for DMP and 4.97% for DEHP. This method was applied for the determination of levels of dimethyl phthalate and di-2-(ethylhexyl) phthalate contamination in solid deodorants. Samples were collected from local markets, department stores and online stores. The result was 1 of 3 samples containing DMP and DEHP. The DMP and DEHP levels were 1.08 ± 0.11% w/w for DMP and 8.39 ± 0.83% w/w for DEHP.

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