PRATIWI, 050810150 (2012) PENGARUH RASIO KETOPROFEN-CARBOXYMETHYL CHITOSAN TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CARBOXYMETHYL CHITOSAN (Dibuat menggunakan metode spray drying). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles of ketoprofen could be developed to decreased gastric irritation and extend absorption that ranging in size from 1 to 1000 μm. The aim of this research was to investigate the effect of ketoprofen-carboxymethyl chitosan (CM Chitosan). Ratio on physical characteristic, drug content, and drug release of microparticles ketoprofen-CM Chitosan. Microparticle with ketoprofen-CM Chitosan ratio 3:15 (F1), 5:15 (F2) and 6: 15 (F3) were prepared by ionic gelation with CaCl2, then dried by spray drying methods. The result showed that CM Chitosan microparticle of ketoprofen have irregular shape. The particle size, drug content, and encapsulation efficiency of microparticles increased by increasing the amount of ketoprofen. In simulated intestinal fluid, the release rate ketoprofen in microparticles was slower that ketoprofen powder. Microparticle with the highest amount of ketoprofen have the fastest release rate.

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