Farah Tsurayya Masturroh, 131111005 (2015) THE EFFECT OF BOILED THE RAMBUTAN FRUIT PEELS ON BLOOD GLUCOSE LEVEL REGULATION IN MICE WITH DIABETES MELLITUS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Diabetes mellitus is a metabolic disorder caused by abnormality secretion of insulin secretion and insulin action in order to decrease glucose absorption in Diabetic case. Naphellium lappaceum Linn is predicted to be able to reduce blood glucose level. In world, Diabetes Mellitus care was 387 million in 2014. This study was used the boiled of Naphellium lappaceum Linn fruit peels as intervention given to male mice of Swiss Webster line. Design used in this study was experimental research design with pre and post-test control group design. Total sampel were 28 mice which divided into four groups: (1) non-intervention positive control group, (2) group with 53,3% concentration of Naphellium lappaceum Linn, (3) group with 26,6% concentration, (4) group with 13,3% concentration. Data were analyzed using One Way Anova. Result showed that group with 53,3% concentration decrease more fasting blood glucose level in mice after intervension (± 80,14 mg/dl). There was significant difference of random blood glucose levels between the control group and the group with 53,3% and 26,6% concentration (p=0,029 and p=0,030). It can be concluded that the boiled of Naphellium lappaceum Linn fruit peel (in 53,3%,dose 0,5 ml/grbb) able to regulate the fasting blood glucose level and inhibit absorption of glucose in the digestive systems of mice with diabetes mellitus

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