MELISA PURNAMASARI, 050810146 (2012) PENGARUH KADAR PEG 8000 TERHADAP LAJU DISOLUSI KURKUMIN DALAM SISTEM DISPERSI PADAT KURKUMIN � PEG 8000. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Curcumin is a substance obtained from Curcuma longa Linn, had wide range of pharmacological activities. Curcumin is insoluble in water and has poor bioavailability. This problem could be resolve by improving drug dissolution. Polyethylene glycol (PEG) 8000 was applied to improve dissolution of curcumin. Curcumin-PEG 8000 solid dispersions in different ratios were prepared. Solid dispersion of curcumin- PEG 800 in the ratio 1:1, 1:2, and 1:4 were prepared with melting-solvent method. Dissolution and powder X-ray diffraction (XRD) of solid dispersion, physical mixture, and pure curcumin were evaluated. Dissolution rate of curcumin indicated a significant increased with increasing amount of PEG 8000 and the result showed that solid dispersion of curcumin-PEG 8000 has the highest dissolution rate among physical mixture and pure curcumin. It was found that solid dispersion with ratio 1:4 has higher dissolution rate than solid dispersion with less PEG 8000. The increased dissolution rate of curcumin may be due to increased wettability. According to XRD studies, solid dispersion as well as physical mixture was present as a crystalline form

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