NOVERIKA ANAMIA PUTRI, 050810181 (2012) PENETRASI NATRIUM DIKLOFENAK SISTEM NIOSOM NATRIUM DIKLOFENAK - SPAN 20 - KOLESTEROL (1:6:6). Skripsi thesis, UNIVERSITAS AIRLANGGA.

Preview	Text (ABSTRAK) gdlhub-gdl-s1-2013-putrinover-22870-7.abstr-.pdf Download (219kB) | Preview
	Text (FULLTEXT) NOVERIKA ANAMIA PUTRI.pdf Restricted to Registered users only Download (0B) | Request a copy

Abstract

This study was designed to determine the profile and penetration rate of diclofenac sodium in the niosome system. Niosome system prepared by the diclofenac sodium, Span 20 and cholesterol with molar ratio of 1:6:6. There were two formulas in this study, in which formula I was diclofenac sodium in the niosome system and formula II was diclofenac sodium that is not in niosome system. Formula I and formula II had a whitish color and a distinctive odor Span 20. Formula I was thicker than formula II. Formula I that used niosome system was not looked spherical and the diameter was between 116,6 nm to 3,754 μm. pH of formula I was 6,84  0,02 and formula II was 6,67  0,02. Entrapment efficiency was 43,68%  0,06. The flux formula I was 1,3062  0,0929 μg/cm2/minute and while formula II was 1,1010  0,1553 μg/cm2/minute. The permeability of membrane to diclofenac sodium in formula I was 1,0985.10-4  5,9919.10-6 cm/minute and the formula II was 9,1736.10-5  1,3089.10-5 cm/minute. The results were analyzed statistically by using independent sample T-test with degree of freedom 4 (df) and degree of confident 95% (α = 0,05). The results revealed that the flux and permeability of membranes formed on diclofenac sodium niosome systems are not different from diclofenac sodium that is not formed system.

Actions (login required)

View Item