LUCIA DWI ELVIRA, 050810194 (2012) PENGARUH KONSENTRASI CHITOSAN 19 cPs TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFEN-CHITOSAN (Dibuat dengan metode spray drying pada suhu inlet 90 oC). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles ketoprofen-chitosan could be developed to decrease gastric irritation and extend absorption. The aim of this research was to investigate the effect of chitosan concentration on physical characteristic, drug entrapment, and drug release of microparticles ketoprofen-chitosan. Microparticles were prepared by ionic gelation and used sodium tripolyphosphate (TPP) as cross linker, and dried by spray drying method. The chitosan concentrations that used in this research were 0,125%(F1), 0,250%(F2) and 0,500%(F3). The result showed that as the chitosan concentration increased, the mean particle size microparticles increased. The result also showed that as the increased of chitosan concentration, the entrapment efficiency of the drugs increased. In simulated intestinal fluid, the release of F2 was slower than F1 and ketoprofen as control.

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