PUTRI ELLYNA MUFIDA, 050810232 (2012) PENGARUH KONSENTRASI CHITOSAN 50 cPs TERHADAP KARAKTERISTIK FISIK DAN PROFIL PELEPASAN MIKROPARTIKEL KETOPROFENCHITOSAN (Dibuat dengan metode spray drying pada suhu inlet 100oC). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Microparticles of ketoprofen could be developed to decrease gastric irritation and extend absorption. The aim of this research was to investigate the effect of chitosan 50 cPs concentration on physical characteristic, drug content, drug entrapment eficiency and drug release of ketoprofen from ketoprofen-chitosan microparticles. Microparticles were prepared by spray drying method in temperature 100oC with differences concentration of chitosan, F1 (0,125% b/v), F2 (0,250% b/v), and F3 (0,500% b/v). The result showed that as the chitosan concentration improved, the mean particle size of microparticles enlarged, content of ketoprofen and drug entrapment efficiency higher. In simulated intestinal fluid (pH 6,8), as the chitosan concentration improved the release of ketoprofen-chitosan microparticles decreased

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