Lutfi Hidiyaningtyas, 051515153015 (2019) ANALISIS KADAR PROCOLLAGEN TYPE 1 AMINOTERMINAL PROPEPTIDE (P1NP) PADA PASIEN DIABETES MELITUS TIPE 2 DENGAN TERAPI PIOGLITAZONE JANGKA PANJANG (Penelitian dilakukan di Poli Penyakit Dalam Instalasi Rawat Jalan RSU Haji Surabaya). Thesis thesis, Universitas Airlangga.

	Text TFK. 27-19 Hid a ABSTRAK.pdf Download (61kB)
	Text TFK. 27-19 Hid a DAFTAR ISI.pdf Download (23kB)
	Text TFK. 27-19 Hid a DAFTAR PUSTAKA.pdf Download (85kB)
	Text (FULLTEXT) TFK. 27-19 Hid a BR.pdf Restricted to Registered users only until 25 November 2022. Download (1MB) | Request a copy

Abstract

Background - Pioglitazone is a member of the thiazolidinedione group of drugs developed for the treatment of type 2 (non–insulin-dependent) diabetes mellitus, a disorder associated with a number of metabolic abnormalities that include impaired insulin secretion and insulin resistance. Post hoc analyses and meta-analyses of adverse event data from randomized controlled trials suggest that treatment with pioglitazone may further increase fracture risk in type 2 diabetes melitus patients. Activation of PPAR-γ and preferential stimulation of the differentiation of bone marrow mesenchymal stem cells into adipocytes at the expense of osteoblasts have been proposed as potential mechanisms for these effects of TZDs on bone. Objective - The aim of this study was to analyze P1NP levels as markers of bone formation, in patients with type 2 diabetes mellitus with long-term pioglitazone therapy. Method - This prospective observational study with cross sectional research design. Blood sampling was taken during the patient's regular visit to the Internal Medicine Outpatient Clinic in the period July - November 2018. Result - 50 patients were participated in this study. 25 patients with non-pioglitazone therapy and 25 patients with pioglitazone therapy for more than 4 months. The mean P1NP level of the non pioglitazone group was 24.02 ± 7.99 ng/ml, and the mean P1NP level of the pioglitazone group was 20 ± 6.83 ng/ml. Statistical analysis showed no significant difference in serum P1NP levels between the two group (p = 0,062). Conclusion - There was no significant difference in P1NP levels in patients with long-term pioglitazone therapy and non-pioglitazone therapy.

Actions (login required)

View Item