Ira Arundina and Indeswati Diyatri and Theresia Indah Budhy S. and Foo Yau Jit (2017) The Effect of Brotowali Stem Extract (Tinospora Crispa) Towards Increasing Number of Lymphocytes in the Healing Process of Traumatic Ulcer on Diabetic Wistar Rat. Journal of International Dental Medical Research, 10 (3). pp. 975-980. ISSN 1309 – 100X

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Abstract

One of the common complication of diabetesis delayed wound healing in oral traumatic ulcer. Lymphocyte cell plays an important role in late inflammatory phase during the process of wound healing. Brotowali (Tinospora crispa) contrains flavonoid and terpenoid which can help to control blood glucose levels and accelerate wound healing. Tinospora crispa extract was made with oven-dried method at 50°C. Dry specimens are then made into a powder and macerated with ethanol 80% (1:10 w/v) The experimental animals were divided into 3 groups, control group 1: Normal Wistar Rat with traumatic ulcer, control group 2:DiabeticWistar rat with traumatic ulcer, and treatment group: Diabetic Wistar rat with traumatic ulcer treated with 250 mg/kg Tinospora crispa extract once a day. All sample were euthanized on day 3, 5, and, 7 after traumatic ulcer was made. Then histopathology preparation was made to count the number of lymphocytes. Blood glucose levels measurement was conducted on day 3, 5, 7, and 14 after traumatic ulcer was made. Kruskal-Wallis test showed a significant difference of blood glucose levels between the control group 1, control group 2 and treatment group. One Way Anova test showed a significant difference of number of lymphocytes between control group 1, control group 2 and treatment group. Brotowali stem extract (Tinospora crispa) is proven to affect blood glucose levels on day 3, 5, 7, and 14. It is also proven that Brotowali stem extract affect the number of lymphocytes in healing of traumatic ulcer among diabetic Wistar rats on day 3, 5, and 7.

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