Theresia Indah Budhy S. and Istiati and Bambang Sumaryono and Ira Arundia and Ririh Setyo Khrisnanthi (2018) Hedyotiscorymbosa (L.) Lamk - The Potential Inhibitor Extract of Oral Cancer Cell Progressivity in Benzopyrene Induced Rattus Novergicus. Journal of International Dental Medical Research, 11 (2). pp. 312-317. ISSN 1309 – 100X

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Abstract

Hedyotiscorymbosa (L.) Lamk produces ursolic acid, an anti-proliferative cancer cell agent which inhibits the progressivity of oral cancer by inhibits proliferation and angiogenesis of cancer cells thus induces cancer cell apoptosis. To determine the potency of Hedyotiscorymbosa (L.) Lamk in different doses (375, 750, and 1500 mg/kg). 25 Rattus novergicus constituted the research sample. They were divided into four groups: Treatment Group 1 receiving a 375mg/kg dose, Treatment Group 2 administered a 750 mg/kg dose, Treatment Group 3 given a 1500mg/kg dose and Treatment Group 4 receiving only distilled water. Oral cavities were induced intramuscularly by 8mg/kg doses of benzopyrene twice a week for four weeks to induce cancer. Hedyotiscorymbosa (L.) Lamk was administered orally for 10 days. All samples were acclimatized to allow performance of HPA examination. HE was used to examine the proliferation of cancer cells. IHC was used to determine caspase-3. Data analyzed by ANOVA. There were significant differences in cancer cell and capillary proliferation between the control and treatment groups. The most significant decrease in cancer cells proliferation and highest caspase-3 expression was found in the group receiving a dose of 750 mg/kg. Hedyotiscorymbosa (L.) Lamk extract could decrease cancer cell and capillary proliferation, thereby increasing apoptosis.

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